MicroRNA-126, -145, and -155

MicroRNA-126 in atherosclerosis.

Silencing MicroRNA-155 Ameliorates

Shhh! Silencing by microRNA-155.

Small RNAs mediate a diverse pot-pourri of post-transcriptional silencing mechanisms, ranging from 'classical' RNA interference (RNAi), to gene repression by microRNAs (miRNAs), to maintenance of genomic stability by repeat-associated small RNAs. Here, we review recent findings on the function of miR-155, particularly its roles in mammalian innate and adaptive immunity, viral infection and onco...

MicroRNA-155 and macrophages: a fatty liaison.

The inflammatory activation of lipid-loaded macrophages in the arterial intima plays a major role in the pathogenesis of atherosclerosis. The unrestricted uptake of oxidatively modified low-density lipoprotein (oxLDL) via scavenger receptors results in the storage of cholesterol esters in lipid droplets in macrophages due to the limited efflux of free cholesterol. However, free cholesterol can ...

MicroRNA-143/-145 in Cardiovascular Diseases

MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of v...